This blog gets a bit technical in places, like right away, and also gets pretty incendiary in its indictment of the horrors generated by arrogant myopic cretinous greedy males, but please plow through it as it is very important to this planet and all upon her.
Mitogen-activated protein kinases (MAPKs), including extracellular-signal–regulated kinases (ERKs), are key players when it comes to governing a vast plethora of very important cellular trajectories including cell proliferation, apoptosis (cell death), and the cell maturation required to perform individual functional roles. There are many ways that ERKs pathways can be activated including cytokines and growth factors as well as estrogens. However, if an estrogen is like a bee trying to land on a flower and trigger a reaction, then a xenoestrogen is like a little tornado tossing that bee about and causing no end of disturbances.
XE’s produce very strong cellular signaling effects similar to the oscillating patterns elicited by E2 where the estrogen alternates turning the signaling up and down over a period of time (technically called a nonmonotonic nongenomic response).
In the graph below the black dots are the “instructions” your estrogen normally gives to cellular signals of how to act and react. The blue diamonds are the same “instructions” when there are xenoestrogens in the body.
As you can see, physiological endogenous estrogens cause changes in ERKs in a way that oscillates with time. Xenoestrogens cause similar but typically smaller changes. However, when they are combined, as they are in almost all humans and most other species on the planet then the changes in the ERK is drastically changed with the frequency and amplitude of the oscillations varying extensively. What this translates to is that all the actions, all of them, that estrogen accomplishes in the body, are either sped up and/or slowed down and/or amplified and/or diminished, sometimes all within 30 minutes. And what is all the more disconcerting is that the xenoestrogen’s yo-yo effects occurring all over the bodymind are often reverse dose dependent, where smaller doses have larger effects. The bodymind’s response profiles are further complicated as the fluctuations are dependent on the life stage the woman/person is in, which is to say dependent on which type of estrogen is dominant, and also on the person’s individual constitution. Does this kind of hard-to-predict weird wavering of your physiology, emotions, temperature, metabolism and even your intellect and anatomy sound at all familiar to you? And I have not even mentioned the epigenetic effects of xenoestrogens.
And what does a typical species’ deep body intelligence do with all this chaotic information caused by toxic xenoestrogens? From an Ayurvedic point of view, one of the themes it may present to the woman’s phenome is like an epigenetic abortion of reproductive ability. The deep intelligence of life and the species suddenly believes that this woman is too unstable to be a suitable mother within the species and that her ability to reproduce should be withdrawn until the time she is healthy enough. What this looks like is the experience of distorted ovulation initially and eventually full menopausal symptoms.
Often the allopathic system looks at normal functions of a woman as a disease, for instance pregnancy and menopause. Of course, we know these are not diseases, but in the case of many women in their 20’s and 30’s, though menopause may not be a disease, for them it is very likely a poisoning. Truly, a woman can be totally healthy, doing all the right practices and protocols, but if there are xenoestrogens in her life, then she may experience quite negative symptoms, as a result of this poisoning.
I know my view could be construed to be harsh, even incendiary, but this is the psyche of life and her strategies being expressed against this insidious power of the xenoestrogens we made that, if left unchecked, could humans to go extinct. I actually really love the irony of it and marvel at the deep wisdom of life at meta-levels where the fullness simply allows dysfunction to dissolve into a random collection of fossils.
Please do not worry about yourself when it comes to xenoestrogens. Worry first about all the species that we have no right to terminate. Then think of the ecosystem in general and worry about how you can protect it. Then worry about those people involved in the manufacture of the xenoestrogens and the application of them, like the farmers! Finally, fifth on the list, if you have any time left, then worry about yourself.